Thermo Fisher Scientific Caspase 1 p10 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• Publications: References

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: Assay-dependent
• Publications: References

Product Specifications

Product Specific Information

• Store as concentrated solution.
• Centrifuge briefly prior to opening vial.
• For short-term storage (1–2 weeks), store at 4°C.
• For long-term storage, aliquot and store at -20°C or below.
• Avoid multiple freeze-thaw cycles.

Target Information

Caspase-1 (CASP1) is a thiol protease that cleaves IL-1 beta between Asp and Ala, leading to release of the mature cytokine involved in inflammatory processes. CASP1 plays a key role in pathogen defense, activates sterol regulatory element binding proteins (SREBPs), and promotes apoptosis. Upon inflammasome activation during DNA virus infection, CASP1 controls antiviral immunity through cleavage and inactivation of CGAS.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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