Thermo Fisher Scientific FUS Recombinant Rabbit Monoclonal Antibody (JJ09-31)
FUS 단백질을 인식하는 재조합 토끼 단일클론 항체로 높은 특이성과 민감도를 제공. Western blot, IHC, Flow cytometry 등 다양한 응용 가능. HEK293 발현 시스템 기반으로 생산되어 로트 간 일관성이 우수함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:5,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 1:1,000 | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | JJ09-31 |
| Immunogen | Synthetic peptide within Human FUS (aa 1–46) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 40% Glycerol, 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809760 |
Product Specific Information
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems developed by cloning specific antibody DNA sequences from immunoreactive rabbits. Individual clones are screened to select the best candidates for production.
Advantages:
- Superior specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulation
- Broader immunoreactivity due to large rabbit immune repertoire
Target Information
The FUS gene encodes a multifunctional protein component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, which is involved in pre-mRNA splicing and export of processed mRNA to the cytoplasm.
It belongs to the FET family of RNA-binding proteins implicated in:
- Regulation of gene expression
- Maintenance of genomic integrity
- mRNA/microRNA processing
Alternative splicing results in multiple transcript variants. Defects in this gene are associated with amyotrophic lateral sclerosis type 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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