Thermo Fisher Scientific AMPD1 Polyclonal Antibody
AMPD1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 ELISA에 적합하며, 인간·마우스·랫트 반응성. 고순도 Affinity chromatography 정제, 안정적인 PBS/glycerol buffer 보존. 연구용으로 근육 대사 및 AMPD1 결핍 연구에 활용 가능.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (aa 1–100 of human AMPD1, UniProt P23109) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2901738 |
Product Specific Information
- Positive Samples: HT-29, Mouse skeletal muscle, Mouse thymus, Mouse pancreas
- Immunogen sequence:
MNVRIFYSVS QSPHSLLSLL FYCAILESRI SATMPLFKLP AEEKQIDDAM RNFAEKVFAS EVKDEGGRQE ISPFDVDEIC PISHHEMQAH IFHLETLSTS
Target Information
AMP deaminase (AMPD) is an allosteric enzyme that regulates adenosine metabolism by catalyzing the deamination of AMP to IMP, releasing ammonia.
Three functional isoforms exist, with AMPD1 (E.C. 3.5.4.6) being the skeletal muscle-specific form found in type II fibers, neuromuscular junctions, and capillaries.
AMPD1 acts as a sensor of cellular energy status. Deficiency leads to irregular muscle metabolism, decreased ATP degradation, and lactic acid accumulation.
Mutations in AMPD1 are linked to neuromuscular disorders, exercise-induced myopathies, and congestive heart failure associated with coronary artery disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: PA5-117108_AMPD1_P23109-1_Rabbit.svg, PA5-117108_AMPD1_P23109-1_Rabbit_PDP.jpeg)
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