Thermo Fisher Scientific Lass5 Polyclonal Antibody
LASS5 단백질을 인식하는 Rabbit Polyclonal 항체로, WB와 IHC에 사용 가능. Human, Mouse, Rat에 반응하며, 항원 친화 크로마토그래피로 정제됨. 세라마이드 합성 관련 연구용에 적합. 냉장 보관(2–8°C) 권장.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14 amino acid peptide near the amino terminus of the human LASS5 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11155009 |
Product Specific Information
- A suggested positive control is SK-N-SH cell lysate.
- PA5-20647 can be used with blocking peptide PEP-0767.
Target Information
The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members (LASS1–6) are involved in ceramide synthesis during cell growth regulation and cancer differentiation.
LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum multi-pass membrane protein. It functions as a dihydro-ceramide synthase, producing sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner.
It uses palmitoyl-CoA as an acyl donor and synthesizes C14, C16, and C18-ceramide. LASS5 is the most abundantly expressed ceramide synthase isoform in lung epithelia and has been shown to partially correct growth and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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