Thermo Fisher Scientific TNPO3 Polyclonal Antibody
TNPO3 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에 반응합니다. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 버퍼에 0.02% sodium azide가 포함되어 있으며, 2-8°C에서 보관 가능합니다.
- 카탈로그번호
- PA520551
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the amino terminus of human TNPO3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152820 |
Product Specific Information
- A suggested positive control is rat liver tissue lysate.
- PA5-20551 can be used with blocking peptide PEP-0671.
Target Information
TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for essential splicing factors termed SR proteins. It binds specifically and directly to the arginine/serine (RS)-rich domains of these proteins, and this interaction occurs only when these RS domains are phosphorylated.
TNPO3 has also been identified as an HIV dependency factor (HDF); depletion of TNPO3 inhibits HIV after reverse transcription but before integration, suggesting TNPO3 may be an important drug target in HIV treatment.
At least three isoforms of TNPO3 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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