Thermo Fisher Scientific KCNMA1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:200

Product Specifications

Product Specific Information

• Reconstitute antibody with 50 µL of double distilled water (DDW).
• Store reconstituted solution at 4°C for up to 1 week.
• For longer storage, aliquot and store at -20°C.
• Avoid repeated freeze-thaw cycles.
• Centrifuge all antibody preparations before use (10,000 × g, 5 min).

GST fusion protein sequence:
SHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRDKQNATRMTRMGQAEKKWFTDEPDNAYPRNIQIKPMSTHMANQINQYKSTSSLIPPIREVEDEC

Homology:

• Mouse: 21/21 amino acids identical to canonical sequence (Accession Q08460)
• Rat: 20/21 amino acids identical (Accession Q62976)
• Human: 19/21 amino acids identical (Accession Q12791)

Target Information

Potassium channels are ubiquitously expressed proteins with diverse roles in excitable and non-excitable cells.
The large conductance, calcium-activated potassium channel (Maxi K⁺) is unique as it is activated by both intracellular calcium increase and membrane depolarization.
Its structure includes a voltage sensor and intracellular calcium-binding domain.
In vascular smooth muscle, an auxiliary β-subunit exists in a 1:1 ratio, reducing the calcium concentration required for channel opening by 5–10 fold.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.