Thermo Fisher Scientific c-Abl Polyclonal Antibody
c-Abl 단백질 인식용 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC(P) 실험에 적합하며 Human, Mouse, Rat 반응성. 고순도(>95%) 항원 친화 크로마토그래피 정제. 연구용으로만 사용 가능.
- 카탈로그번호
- PA586077
- 판매단위
- pk
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Thermo Fisher Scientific c-Abl Polyclonal Antibody
Applications and Tested Dilution
- Western Blot (WB): 1:500–1:1,000
- Immunohistochemistry (Paraffin) [IHC (P)]: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 171–120 of Human ABL1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_2802877 |
Product Specific Information
- Purity is >95% by SDS-PAGE.
Target Information
ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase involved in cell differentiation, division, adhesion, and stress response. c-Abl activity is negatively regulated by its SH3 domain; deletion of this domain converts c-Abl into an oncogene. DNA-binding activity is regulated by CDC2-mediated phosphorylation, indicating a role in the cell cycle. In chronic myelogenous leukemia and some acute lymphoblastic leukemias, c-Abl undergoes a (9;22) translocation forming the Philadelphia chromosome, fusing c-Abl with the Bcr gene. The c-Abl oncogene was first identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). c-Abl also contributes to DNA repair regulation and apoptosis activation upon severe DNA damage.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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