Thermo Fisher Scientific ATG13 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:1,000

ELISA

• Tested Dilution: 1:220,000–1:250,000

Product Specifications

Product Specific Information

Store vial at -20°C prior to opening.
Aliquot contents and freeze at -20°C or below for extended storage.
Avoid cycles of freezing and thawing.
Centrifuge product if not completely clear after standing at room temperature.
Stable for several weeks at 4°C as an undiluted liquid.
Dilute only prior to immediate use.

This affinity-purified antibody is directed against human ATG13 protein.
A BLAST analysis suggests cross-reactivity with ATG13 from human based on 100% sequence homology with the immunogen.
Reactivity against homologues from other sources is not known.

Target Information

Autophagy is a process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway, essential for normal growth control and nutrient preservation under starvation conditions.
ATG13 forms a complex with ULK1, ULK2, and FIP200, and is regulated by TOR (Target of rapamycin).
Inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1, and ULK2, inducing autophagy.
Knockdown of ATG13 inhibits autophagosome formation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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