Thermo Fisher Scientific ENO1 Polyclonal Antibody
Thermo Fisher Scientific의 ENO1 Polyclonal Antibody는 인간 및 마우스 반응성을 가지며 Western blot, IHC, ICC, Flow cytometry에 적합합니다. KLH 결합 합성 펩타이드 면역원으로 제작된 Rabbit IgG 항체로, 2 mg/mL 농도의 액상 형태입니다. 연구용으로 다양한 종에서 예측 반응성을 보입니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 178–205 amino acids from the central region of human ENO1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2099065 |
Product Specific Information
This antibody is predicted to react with bovine, chicken, non-human primate, rat, and Xenopus based on sequence homology.
Target Information
Enolase (2-phosphoglycerate hydrolyase or phosphopyruvate hydrates) is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. It consists of three subunits: alpha, beta, and gamma.
Non-neuronal enolase (ENO1) is an isoform composed of two alpha subunits. The ENO1 gene also encodes a shorter monomeric structural lens protein, tau-crystallin.
This multifunctional enzyme contributes to glycolysis, growth control, hypoxia tolerance, and allergic responses. It may act in the fibrinolytic system by serving as a receptor and activator of plasminogen on cell surfaces such as leukocytes and neurons. ENO1 stimulates immunoglobulin production and is used as a diagnostic marker for various tumors.
In its alpha/gamma heterodimeric form, it serves as a marker for hypoxic brain injury after cardiac arrest and endometriosis. Antibodies against alpha-enolase are found in sera from patients with cancer-associated retinopathy syndrome (CAR). ENO1 is also identified as an autoantigen in Hashimoto encephalopathy (HE), a rare autoimmune disease associated with Hashimoto thyroiditis (HT).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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