Thermo Fisher Scientific IRF4 Polyclonal Antibody
Human IRF4 단백질에 특이적인 Rabbit Polyclonal Antibody. Western blot 및 IHC(Paraffin) 응용에 적합. 항원 친화 크로마토그래피로 정제된 액상 형태로 제공되며, PBS/글리세롤 버퍼에 보관. 연구용으로만 사용 가능.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Horse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human IRF4. Recombinant protein control fragment (Product #RP-101886) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2789160 |
Product Specific Information
Immunogen sequence:
SNDFEELVER SQLDISDPYK VYRIVPEGAK KGAKQLTLED PQMSMSHPYT MTTPYPSLPA QQVHNYMMPP LDRSWRDYVP DQPHPEIPYQ CPMTFGPRGH HWQGPACENG CQVTGTFYAC APPE
Target Information
The IRF (interferon regulatory factor) family of transcription factors are characterized by a unique tryptophan pentad repeat DNA-binding domain. The IRFs regulate interferons in response to viral infection and control interferon-inducible genes.
IRF4 is lymphocyte-specific and negatively regulates toll-like receptor (TLR) signaling, central to innate and adaptive immune activation.
A chromosomal translocation involving IRF4 and the IgH locus, t(6;14)(p25;q32), may be associated with multiple myeloma. Alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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