Thermo Fisher Scientific TIMP2 Polyclonal Antibody
Rabbit polyclonal antibody against human TIMP2 for Western blot applications. High specificity without cross-reactivity to other TIMP family members. Supplied as a liquid at 1 mg/mL, purified by antigen affinity chromatography. Suitable for research us...
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Applications
- Western Blot (WB)
Tested Dilution: 1:1,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the first loop domain of human TIMP2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2204962 |
Product Specific Information
This antibody does not cross-react with other TIMP family members (TIMP1, TIMP3, TIMP4).
Target Information
TIMP-1 and TIMP-2 are inhibitory enzymes of the matrix metalloproteinase family and play a crucial role in maintaining connective tissue integrity.
TIMP-2 has high binding affinity to both latent (pro) and active forms of 72 kDa Type IV collagenase (MMP-2, gelatinase A) and also binds to the active form of 92 kDa Type IV collagenase (MMP-9, gelatinase B).
It inhibits proteolytic invasiveness of tumor cells and normal placental trophoblast cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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