Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), eBioscience
인간 IL-17A를 인식하는 중화능 단클론 항체로, 염증성 질환 연구에 적합. IHC, ELISA, Flow Cytometry 등 다양한 응용 가능. SDS-PAGE 기준 90% 이상 순도, PBS 버퍼에 0.09% sodium azide 포함. 4°C 보관, 연구용 전용 제품.
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Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17)
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 4 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | 1 publication |
| Immunocytochemistry (ICC/IF) | - | 7 publications |
| Flow Cytometry (Flow) | - | 46 publications |
| ELISA | Assay-Dependent | 5 publications |
| Neutralization (Neu) | - | 3 publications |
| Radioimmune Assays (RIA) | - | 1 publication |
| In vitro Assay (IV) | - | 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Hamster, Human, Mouse, Non-human primate, Rat, Rhesus monkey, Sheep |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio64DEC17 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2865271 |
| Purity | >90% (SDS-PAGE) |
| Aggregation | <10% (HPLC) |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Conjugated Formats
- Alexa Fluor 488
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 563
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 605
- Brilliant Violet 786
- eFluor 450
- eFluor 506
- eFluor 660
- FITC
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Request custom conjugation available
Product Specific Information
The eBio64DEC17 antibody reacts with human IL-17A and functions as a neutralizing antibody. IL-17A is a CD4+ T cell-derived cytokine promoting inflammatory responses and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
IL-17A exists as glycosylated 20–30 kD homodimers and enhances ICAM-1 expression in fibroblasts. It stimulates epithelial and endothelial cells to secrete IL-6, IL-8, G-CSF, and PGE2, and supports CD34+ progenitor proliferation and neutrophil maturation.
IL-23-dependent Th17 cells represent a distinct CD4+ subset, negatively regulated by IFN-γ and IL-4. Intracellular staining by eBio64DEC17 identifies the same cell population as eBio64CAP17.
Applications Reported: Immunohistology staining and ELISA
Applications Tested: ELISA
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine that promotes inflammatory responses and is elevated in autoimmune and inflammatory diseases. It is a 32 kDa disulfide-linked homodimer of 136 amino acids, signaling through IL-17R/CDw217.
IL-17A regulates NF-κB and MAPK activities, stimulates IL-6 and COX-2 expression, and enhances nitric oxide production. It plays a key role in inflammation and immune regulation across multiple species.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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