Thermo Fisher Scientific ERBB3 Monoclonal Antibody (OTI1C6), TrueMAB
ERBB3 단백질을 인식하는 Mouse Monoclonal Antibody로 Western Blot 및 IHC(P) 검증됨. 인간 시료에 반응하며, Lyophilized 형태로 제공. 재구성 후 약 1 mg/mL 농도로 사용 가능. 연구용으로 세포 신호전달 및 암 관련 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1C6 |
| Immunogen | Full length human recombinant protein of human ERBB3 produced in SF9 cell. Target family: Her-3 (ErbB3), UniProt ID: P21860-1, NCBI Node ID: 9606, Antigen range: 1–1342, Antigen length: 1342 |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, an additional desalting step is recommended (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors that binds to heregulin family ligands.
It is overexpressed in various tumors including prostate, bladder, breast, stomach, pancreas, and colon cancers.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to varying degrees.
The ErbB3 gene, located on chromosome 12q13, encodes a 160/180 kDa glycoprotein.
It forms heterodimers with other EGF receptor family members, activating pathways involved in cell proliferation and differentiation.
Alternative splice variants exist, including a secreted isoform that modulates membrane-bound receptor activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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