Thermo Fisher Scientific SCF Polyclonal Antibody

Thermo Fisher Scientific SCF Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Suggested positive control: rat brain tissue lysate
• PA5-20746 can be used with blocking peptide PEP-0860
• Avoid exposure to prolonged high temperatures

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression promotes mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting its potential as a therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.