Thermo Fisher Scientific SCF Polyclonal Antibody
SCF 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal antibody로, WB 및 IHC에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태이며, 4°C 보관. 연구용으로 적합.
- 카탈로그번호
- PA520746
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific SCF Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1–2 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | – | View 3 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5 µg/mL | – |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 20 µg/mL | – |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide from near the center of human SCF |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11151864 |
Product Specific Information
- Suggested positive control: rat brain tissue lysate
- PA5-20746 can be used with blocking peptide PEP-0860
- Avoid exposure to prolonged high temperatures
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase. SCF expression promotes mast cell survival and the release of histamine, pro-inflammatory cytokines, and chemokines. Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness, suggesting its potential as a therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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