Thermo Fisher Scientific CD43 Monoclonal Antibody (DFT-1), FITC
FITC 형광 표지된 CD43 단클론 항체로 인간 세포 분석에 적합. Flow cytometry 및 immunocytochemistry에 사용 가능. 단백질 A 정제, PBS 및 BSA 버퍼 포함. 4°C 단기, -20°C 장기 보관 권장.
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Thermo Fisher Scientific CD43 Monoclonal Antibody (DFT-1), FITC
Applications
Immunocytochemistry (ICC/IF)
Tested dilution: Not specified
View 1 publicationFlow Cytometry (Flow)
Tested dilution: Neat
View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | DFT-1 |
| Immunogen | KG-1 cells |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; -20°C long term (avoid freeze/thaw cycles). Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538141 |
Product Specific Information
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.
Target Information
CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, but can also promote leukocyte aggregation.
By interaction with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic.
CD43 signaling enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 can induce functionally active tumor suppressor p53 protein, but in cases of p53 and ARF deficiency, CD43 promotes tumor proliferation and viability.
Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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