Thermo Fisher Scientific CD43 Monoclonal Antibody (DFT-1), FITC

Thermo Fisher Scientific CD43 Monoclonal Antibody (DFT-1), FITC

Applications

• Immunocytochemistry (ICC/IF)
  Tested dilution: Not specified
  View 1 publication

• Flow Cytometry (Flow)
  Tested dilution: Neat
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Product Specifications

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10^6 cells in 100 µL.

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with high negative charge, expressed on the surface of most hematopoietic cells. CD43 contributes to a repulsive barrier that interferes with cellular adhesion, but can also promote leukocyte aggregation.
By interaction with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte traffic.
CD43 signaling enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors. Expression of CD43 can induce functionally active tumor suppressor p53 protein, but in cases of p53 and ARF deficiency, CD43 promotes tumor proliferation and viability.
Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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