Thermo Fisher Scientific Dynamin 1 Polyclonal Antibody

Thermo Fisher Scientific Dynamin 1 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Catalog No: PA1-660
• Detects dynamin I (Dyn1) from rat tissues.
• Suitable for Western blot and immunocytochemical procedures.
• Detects ~100 kDa protein representing Dyn1 from rat whole brain extract.
• Immunizing peptide corresponds to amino acid residues 633–647 from rat Dyn1, conserved in rat, mouse, and human.
• Immunizing peptide (Cat. # PEP-042) available for neutralization and control experiments.

Target Information

Dynamin is a GTPase required for endocytosis of clathrin-coated vesicles from the membrane. Its role in endocytosis was first identified in Drosophila melanogaster.
Three isoforms exist in mammals:

• Dynamin 1: Expressed in neurons
• Dynamin 2: Ubiquitously expressed
• Dynamin 3: Expressed primarily in testes

Each isoform has multiple splice variants, suggesting distinct intracellular functions.
Common structural domains include:

• N-terminal GTPase domain
• Central pleckstrin homology domain
• C-terminal proline-rich region with SH3 domains

Dynamin interacts with AP2 adaptor protein complex and amphiphysin, targeting clathrin-coated pits.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.

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