Thermo Fisher Scientific Phospho-LATS1/LATS2 (Thr1079, Thr1041) Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide sequence around phosphorylation site of threonine 1079/1041 (E-F-T(p)-F-R) derived from Human LATS1/2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LATS1/LATS2,uniProtId:O95835-1,ncbiNodeId:9606,antigenRange:1039-1043|1077-1081,antigenLength:1130,antigenImageFileName:PA5-37834_LATS1LATS2_O95835-1_Rabbit.svg,antigenImageFileNamePDP:PA5-37834_LATS1LATS2_O95835-1_Rabbit_PDP.jpeg,sortOrder:1},{targetFamily:LATS1/LATS2,uniProtId:Q9NRM7-1,ncbiNodeId:9606,antigenRange:1039-1043|1077-1081,antigenLength:1088,antigenImageFileName:PA5-37834_LATS1LATS2_Q9NRM7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-37834_LATS1LATS2_Q9NRM7-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2554442

Product Specific Information

A suggested positive control for IHC is human brain tissue.

Target Information

The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.