Thermo Fisher Scientific Human IL-8 (CXCL8) (Endothelial-derived) Recombinant Protein
Human IL-8 (CXCL8) 재조합 단백질로, E. coli 발현 시스템에서 생산된 고순도(>98%) 단백질입니다. 염증 반응 관련 연구 및 세포 화학유인 실험에 적합하며, 기능적 활성(ED50 = 25–150 ng/mL)을 검증했습니다. Carrier-free 형태로 제공되며, 장기 보관 시 -20°C 이하에서 안정적입니다.
- 카탈로그번호
- PHC0084
- 카테고리
- Protein
- 판매단위
- pk
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Applications
- Western Blot (WB): Assay-dependent
- Immunohistochemistry (IHC): Assay-dependent
- ELISA: Assay-dependent
- Functional Assay: Assay-dependent
- Control (Ctrl): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Expression System | E. coli |
| Amino Acid Sequence | Human IL-8 recombinant protein contains 77 amino acids |
| Molecular Weight | 8.9 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | >98% by SDS-PAGE |
| Endotoxin Concentration | <0.1 ng/µg |
| Activity | ED50 = 25 - 150 ng/mL; determined by the ability to chemoattract human peripheral blood neutrophils |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Wet or Dry ice (international) |
Product Specific Information
Carrier-Free
Reconstitution:
Briefly centrifuge vial before opening. Reconstitute IL-8 in water to 0.1–1.0 mg/mL. Do not vortex.
Store solution at 2°C–8°C for up to 1 week.
For extended storage, dilute in buffer containing 0.1% BSA and store aliquots at -20°C to -80°C.Storage:
Lyophilized protein stable at room temperature for 1 month; store at -20°C for long-term.
Working aliquots with carrier protein are stable ≥3 months at -20°C to -80°C.
Avoid repeated freeze/thaw cycles.
Target Information
Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory chemokine belonging to the CXC subfamily. It binds to IL-8RA and IL-8RB receptors and acts as a chemoattractant and angiogenic factor.
IL-8 expression is induced by inflammatory stimuli in various cells, including macrophages and endothelial cells, and is stored in Weibel-Palade bodies in endothelial cells.
It contains an ELR motif (N-terminal Glu-Leu-Arg) and signals through CXCR1 and CXCR2 receptors.
Alternative names include NAP-1, GCP-1, MONAP, and protein 3-10C.
IL-8 and related CXC chemokines form a gene cluster on chromosome 4q.
Studies suggest IL-8 plays roles in tumor angiogenesis and bronchiolitis pathogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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