Thermo Fisher Scientific PDGFRB Polyclonal Antibody
PDGFRB 단백질을 인식하는 Thermo Fisher Scientific의 토끼 다클론 항체. Western blot, IHC, ICC/IF, Flow Cytometry 등 다양한 응용 가능. 2 mg/mL 농도의 액상 형태로 제공되며, PBS에 0.09% sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 | - |
| Immunocytochemistry (ICC/IF) | 1:10–1:50 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
| Functional Assay | - | 1 publication |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 40–72 from the N-terminal region of human PDGFRB (CD140b, UniProt ID: P09619-1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1958761 |
Product Specific Information
- Recommended positive control: THP-1 cell lysate
- Store product as a concentrated solution.
- Centrifuge briefly before opening the vial.
Target Information
PDGFRB (Platelet-Derived Growth Factor Receptor Beta) is a receptor tyrosine kinase implicated in atherogenesis and cell transformation by the SIS oncogene. These growth factors act as mitogens for cells of mesenchymal origin. The receptor forms homo- or heterodimers depending on the ligand bound. The PDGFRB gene is located on chromosome 5, adjacent to genes for GM-CSF and M-CSF receptor, all potentially involved in the 5q- syndrome. A translocation between chromosomes 5 and 12 fusing PDGFRB (CD140b) with ETV6 results in chronic myeloproliferative disorder with eosinophilia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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