Thermo Fisher Scientific ROS1 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• HL-60 cell lysate may be used as a positive control for this product.
• Store product as a concentrated solution.
• Centrifuge briefly prior to opening the vial.

Target Information

ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the γ phosphate of ATP, onto an acceptor amino acid in a substrate protein.
By this mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, cell movement, apoptosis, and differentiation.

With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes.
The family is classified into 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains.
The tyrosine kinase (TK) group is mainly involved in regulation of cell-cell interactions such as differentiation, adhesion, motility, and death.
There are currently about 90 TK genes sequenced: 58 receptor protein TKs (e.g., EGFR, EPH, FGFR, PDGFR, TRK, VEGFR families) and 32 cytosolic TKs (e.g., ABL, FAK, JAK, SRC families).

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.