Thermo Fisher Scientific CD43 Recombinant Rabbit Monoclonal Antibody (SPN, 1766R)

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Immunohistochemistry (PFA fixed): Incubate antibody for 30 min at room temperature.
• Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

CD43 (leukosialin, sialophorin) is a transmembrane mucin-like protein with a high negative charge, expressed on the surface of most hematopoietic cells.
It contributes to a repulsive barrier that interferes with cellular adhesion but can also promote leukocyte aggregation.
Through interaction with actin-binding proteins ezrin and moesin, CD43 regulates T-cell morphology and cell-cell interactions during lymphocyte trafficking.
CD43 signaling enhances LFA-1 adhesiveness and counteracts LFA-1 induction via other receptors.
Expression of CD43 induces functionally active tumor suppressor p53 protein; however, in p53 and ARF deficiency, CD43 promotes tumor proliferation and viability.
Diseases associated with CD43 dysfunction include Wiscott-Aldrich Syndrome and Adenoid Basal Cell Carcinoma.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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