Thermo Fisher Scientific SETD7 Polyclonal Antibody
SETD7 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. WB, ICC/IF, ELISA에 사용 가능하며, 핵 내 SETD7 단백질 검출에 적합합니다. Affinity 정제 및 PBS/glycerol buffer로 안정화되어 있습니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1–366 of human SETD7 (NP_0851511) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.48 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2809122 |
Product Specific Information
Immunogen sequence:
MDSDDEMVEE AVEGHLDDDG LPHGFCTVTY SSTDRFEGNF VHGEKNGRGK FFFFDGSTLE GYYVDDALQG QGVYTYEDGG VLQGTYVDGE LNGPAQEYDT DGRLIFKGQY KDNIRHGVCW IYYPDGGSLV GEVNEDGEMT GEKIAYVYPD ERTALYGKFI DGEMIEGKLA TLMSTEEGRP HFELMPGNSV YHFDKSTSSC ISTNALLPDP YESERVYVAE SLISSAGEGL FSKVAVGPNT VMSFYNGVRI THQEVDSRDW ALNGNTLSLD EETVIDVPEP YNHVSKYCAS LGHKANHSFT PNCIYDMFVH PRFGPIKCIR TLRAVEADEE LTVAYGYDHS PPGKSGPEAP EWYQVELKAF QATQQK
Positive Samples: HeLa, HepG2, Mouse pancreas, Mouse brain, Rat brain
Cellular Location: Chromosome, Nucleus
Target Information
Histone methyltransferase that specifically monomethylates Lys-4 of histone H3.
H3 Lys-4 methylation acts as a tag for epigenetic transcriptional activation.
SETD7 plays a central role in activating genes such as collagenase and insulin by being recruited to promoters through IPF1/PDX-1.
It also methylates non-histone proteins including p53/TP53 and TAF10, enhancing transcriptional activity and protein stability.
Monomethylation of Lys-189 of TAF10 increases its affinity for RNA polymerase II, while methylation of Lys-372 of p53 stabilizes and activates p53-mediated transcription.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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