Thermo Fisher Scientific CaMKII alpha Polyclonal Antibody
CaMKII alpha 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체입니다. Western blot, IHC, ICC/IF에 사용 가능하며 인간, 생쥐, 랫트 반응성을 가집니다. 고순도 친화 크로마토그래피 정제, 액상 형태로 -20°C 보관.
- 카탈로그번호
- PA5114938
- 판매단위
- pk
카탈로그
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1:50–1:200
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human CAMK2A (Accession Q9UQM7), corresponding to amino acid residues P211–T261 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899574 |
Product Specific Information
Antibody detects endogenous levels of total CaMKII.
Target Information
CAMK2A (CaMKII alpha) is a serine/threonine kinase that regulates numerous cellular functions, including neuronal processes, gene expression, carbohydrate metabolism, cytoskeletal function, and calcium homeostasis.
Autophosphorylation of threonine 286 in the presence of Ca²⁺ and calmodulin activates CAMK2A, allowing it to switch from calmodulin-dependent to calmodulin-independent activity.
CaMKII is ubiquitously expressed and implicated in cell cycle regulation, transcription, dendritic spine and synapse formation, neuronal plasticity, and sarcoplasmic reticulum Ca²⁺ transport in skeletal muscle.
In neurons, it plays an essential structural role in actin cytoskeleton reorganization during plasticity by binding and bundling actin filaments in a kinase-independent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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