Thermo Fisher Scientific CamK4 Polyclonal Antibody
Rabbit polyclonal antibody targeting human CaMKIV, suitable for IHC and IHC (Paraffin) applications. High specificity and affinity purified. Supplied as liquid form, unconjugated, with 0.5 mg/mL concentration. Recommended storage at 4°C, research use o...
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- IHC00042x (2개 옵션)
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Applications
Immunohistochemistry (IHC)
- Tested Dilution: 1:100–1:500
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 425 and the C-terminus (residue 473) of human Calcium/Calmodulin-dependent Protein Kinase IV |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.50 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Based on 100% sequence identity, this antibody is predicted to react with Gorilla, Chimpanzee, Northern white-cheeked gibbon, and White-tufted-ear marmoset
Target Information
CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.
The nuclear localization of this protein supports its role in mediating calcium-dependent gene expression. CaMKIV is abundant in testis, T-cells, and neurons but also found in other tissues.
In neurons, CaMKIV contributes to synaptic plasticity via gene regulation. In T-cells, it plays a role in calcium signaling affecting NFAT activation. CaMKIV and calspermin are encoded by the CaMKIV gene. In testes, CaMKIV associates with chromatin, suggesting a role in chromatin remodeling during spermatid nuclear condensation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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