Thermo Fisher Scientific CamK4 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: 1:100–1:500

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:500

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Based on 100% sequence identity, this antibody is predicted to react with Gorilla, Chimpanzee, Northern white-cheeked gibbon, and White-tufted-ear marmoset

Target Information

CAMK4 (CaMKIV) is a serine/threonine protein kinase that phosphorylates CREB, oncoprotein 18, and SRF. It has limited tissue distribution and is implicated in transcriptional regulation in lymphocytes, neurons, and male germ cells.
The nuclear localization of this protein supports its role in mediating calcium-dependent gene expression. CaMKIV is abundant in testis, T-cells, and neurons but also found in other tissues.
In neurons, CaMKIV contributes to synaptic plasticity via gene regulation. In T-cells, it plays a role in calcium signaling affecting NFAT activation. CaMKIV and calspermin are encoded by the CaMKIV gene. In testes, CaMKIV associates with chromatin, suggesting a role in chromatin remodeling during spermatid nuclear condensation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.