Thermo Fisher Scientific CD8 alpha Recombinant Rabbit Monoclonal Antibody (BLR154J)
CD8 alpha 단백질을 인식하는 재조합 토끼 단일클론 항체로, Western blot 및 IHC에 적합합니다. HEK293F 발현 시스템에서 생산되었으며, 인간 시료에 반응합니다. 1 mg/mL 농도의 액상 형태로 제공되며, 4°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR154J |
| Immunogen | Recombinant protein representing the extracellular domain of Human T-cell surface glycoprotein CD8 alpha (residues 22–180) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin family that plays an integral role in signal transduction, T cell differentiation, and activation. CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules. CD8α is essential for MHC-I binding and is also expressed on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers. Interaction with MHC-I/peptide complexes triggers Lck recruitment, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are crucial for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: A700-154CF_CD8_P01732-1_Rabbit.svg / A700-154CF_CD8_P01732-1_Rabbit_PDP.jpeg)
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