Thermo Fisher Scientific NCAM-1/CD56 Recombinant Rabbit Monoclonal Antibody (BLR152J)
Thermo Fisher Scientific의 NCAM-1/CD56 재조합 토끼 단클론 항체(BLR152J)는 인간 시료에 반응하며, WB, IHC, ICC/IF 등 다양한 분석에 사용 가능합니다. HEK293F 발현 시스템에서 생산된 고순도 항체로, 신경세포 접착 분자 연구에 적합합니다.
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Applications
Western Blot (WB)
- Tested Dilution: Assay-dependent
Immunohistochemistry (IHC)
- Tested Dilution: Assay-dependent
Immunocytochemistry (ICC/IF)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | BLR152J |
| Immunogen | Recombinant protein representing the extracellular domain of Human Neural Cell Adhesion Molecule 1 (NCAM1/CD56, residues 20–318) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | BBS, pH 8.2 |
| Contains | 0.09% Sodium Azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
CD56 (NCAM, neural cell adhesion molecule) is a transmembrane glycoprotein belonging to the immunoglobulin family. It functions as an adhesive molecule and is widely expressed in the nervous system in isoforms ranging from 120–180 kDa.
CD56 is present on T cells and NK cells and plays roles in cell migration, axonal growth, pathfinding, and synaptic plasticity. Polysialic modification reduces CD56-mediated adhesion.
Through its extracellular region, CD56 mediates homophilic and heterophilic interactions with extracellular matrix components such as laminin and integrins.
It is expressed on most neuroectodermal-derived cell lines, tissues, and tumors such as retinoblastoma, medulloblastoma, astrocytoma, and neuroblastoma.
CD56 is also a sensitive neuroendocrine marker for neuroendocrine tumors and ovarian granulosa cell tumors.
Diseases associated with CD56 dysfunction include rabies and blastic plasmacytoid dendritic cell neoplasms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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