Thermo Fisher Scientific CRHBP Monoclonal Antibody (3D9)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Protein sequence:

MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC 
LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG 
EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL 
FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI 
GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ 
LEPYELENPN GNSIGEFCLS GL

Target Information

Response to stress in mammals requires an intact hypothalamic-pituitary-adrenal axis. The proximal part of the response is mediated by secretion of corticotropin-releasing hormone (CRH) by the paraventricular nucleus of the hypothalamus. CRH is a 41 amino acid peptide derived from a 191 amino acid preprohormone and is produced in both hypothalamus and peripheral tissues such as T lymphocytes and placenta. Glucocorticoids stimulate placental CRH synthesis, contrasting with suppression in the hypothalamus.
Human plasma contains a CRH-binding protein (CRH-BP or CRF-BP) that inactivates CRH and may prevent inappropriate pituitary-adrenal stimulation during pregnancy. The CRH gene maps to chromosome 8q13, and CRF-BP maps to chromosome 5q11.2–q13.3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.