Thermo Fisher Scientific CRX Monoclonal Antibody (2F12)
CRX 단백질을 표적하는 mouse monoclonal antibody (clone 2F12)로, Western blot 및 ELISA에 적합합니다. 인간 및 랫트 시료 반응성이 있으며, PBS buffer에 보존된 액상 형태로 제공됩니다. 시냅스 및 시각 관련 유전자 연구에 유용한 연구용 시약입니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1–5 µg/mL
ELISA
- Tested Dilution: 0.1 ng/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2F12 |
| Immunogen | CRX (NP_000545, 1–95 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein:
MMAYMNPGPH YSVNALALSG PSVDLMHQAV PYPSAPRKQR RERTTFTRSQ LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRTarget Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that coordinates the expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin. Specifically, CRX binds the OTX motif (TAATCC/A) upstream from photoreceptor genes.
CRX is also expressed in pinealocytes of the pineal gland and may regulate circadian activity by controlling melatonin synthesis gene expression.
CRX(-) mice show disruption of circadian rhythms. The human CRX gene maps to chromosome 19q13.3 within the cone-rod dystrophy-2 locus (CORD2).
Mutations in CRX are implicated in CORD, Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP). All characterized CRX mutations cause disease in heterozygotes, though phenotype–mutation correlation is not established. Missense mutations affect the homeobox domain, while frameshift mutations affect the OTX domain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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