Thermo Fisher Scientific CRX Monoclonal Antibody (F6-C2)
CRX 단백질을 인식하는 Mouse monoclonal antibody (Clone F6-C2)로, Western blot 및 ELISA에 적합합니다. Human 시료 반응성이 있으며, Affinity chromatography로 정제된 액상 제품입니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| ELISA | 1 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | F6-C2 |
| Immunogen | CRX (AAH16664, 1 a.a. ~ 300 a.a.) full-length recombinant protein with GST tag (GST tag MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Protein sequence:
MMAYMNPGPH YSVNALALSG PSVDLMHQAV PYPSAPRKQR RERTTFTRSQ LEELEALFAK TQYPDVYARE EVALKINLPE SRVQVWFKNR RAKCRQQRQQ QKQQQQPPGG QAKARPAKRK AGTSPRPSTD VCPDPLGISD SYSPPLPGPS GSPTTAVATV SIWSPASESP LPEAQRAGLV ASGPSLTSAP YAMTYAPASA FCSSPSAYGS PSSYFSGLDP YLSPMVPQLG GPALSPLSGP SVGPSLAQSP TSLSGQSYGA YSPVDSLEFK DPTGTWKFTY NPMDPLDYKD QSAWKFQIL
Target Information
The cone-rod homeobox-containing gene (CRX) encodes a transcription factor that regulates expression of several photoreceptor genes in the developing retina, including opsin and rhodopsin.
CRX binds the OTX motif (TAATCC/A) upstream of photoreceptor genes and is also expressed in pinealocytes, potentially influencing melatonin synthesis and circadian rhythm regulation.
Mutations in the CRX gene are associated with cone-rod dystrophy (CORD), Leber congenital amaurosis (LCA), and retinitis pigmentosa (RP).
The human CRX gene is located on chromosome 19q13.3 within the CORD2 locus.
Missense mutations affect the homeobox domain, while frameshift mutations impact the OTX domain.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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