Thermo Fisher Scientific CACNA1G, CACNA1H Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• The peptide is homologous in rat and mouse.
• Specificity: CACNA1G and CACNA1H.

Target Information

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are involved in various calcium-dependent processes such as muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division, and cell death.
The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the low-voltage activated (LVA) group and are strongly blocked by mibefradil. These channels open at negative potentials and exhibit voltage-dependent inactivation.
T-type channels serve pacemaking functions in central neurons and cardiac nodal cells, supporting calcium signaling in secretory and vascular smooth muscle cells. They may also modulate neuronal firing patterns, important for information processing and cell growth.
There are two isoforms of CACNA1H and 14 isoforms of CACNA1G, produced by alternative splicing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.