Thermo Fisher Scientific FGFR4 Monoclonal Antibody (4H2B10B2)
FGFR4 단백질을 인식하는 Thermo Fisher Scientific의 mouse monoclonal antibody로, Human 시료에 반응합니다. WB, IHC, ELISA에 적합하며, 비결합형 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4H2B10B2 |
| Immunogen | Purified recombinant fragment of FGFR4 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10981115 |
Product Specific Information
MA5-15350 targets FGFR4 in indirect ELISA, IHC, and WB applications, showing reactivity with human samples.
The immunogen is a purified recombinant fragment of FGFR4 expressed in E. coli.
MA5-15350 detects FGFR4, which has a predicted molecular weight of approximately 88 kDa.
Target Information
FGFR4 is a member of the FGFR family of receptor tyrosine kinases. This family regulates numerous cellular functions, including angiogenesis, mitogenesis, osteogenesis, myogenesis, carcinogenesis, cellular differentiation, and tissue repair after injury.
FGFR family proteins are implicated in diseases such as cancer, rheumatoid arthritis, and diabetic retinopathy.
FGFR4 is required for normal down-regulation of CYP7A1 expression, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. It also plays roles in postnatal lung development and skeletal muscle lineage formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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