Thermo Fisher Scientific CD163 Monoclonal Antibody (GHI/61)
인간 CD163 단백질을 표적으로 하는 Mouse IgG1 단클론 항체. WB, IHC, Flow Cytometry, IP 등 다양한 응용에 적합. 단백질 G 정제, PBS 버퍼 및 sodium azide 포함. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific CD163 Monoclonal Antibody (GHI/61)
Applications and Tested Dilutions
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | Assay-dependent | |
| Immunohistochemistry (IHC) | – | |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:500 | |
| Immunohistochemistry (Frozen) (IHC-F) | Assay-dependent | |
| Flow Cytometry (Flow) | Assay-dependent | |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | GHI/61 |
| Immunogen | Mouse monoclonal antibodies raised against human CD163 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2539106 |
Available Conjugated Formats
Product Specific Information
MA5-17716 targets CD163/M130 in FACS, IHC (F), IP, and WB applications and shows reactivity with Human samples.
The MA5-17716 immunogen is mouse monoclonal antibodies raised against human CD163.
Target Information
CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein belonging to the scavenger receptor cysteine-rich superfamily. It acts as a receptor for the hemoglobin-haptoglobin complex, protecting tissues from oxidative damage and participating in iron recycling via endocytosis and heme breakdown.
CD163 is expressed on the surface of human monocytes and macrophages predominantly during the late phase of inflammation. It is found on all circulating monocytes and most tissue macrophages, except those in mantle zones and germinal centers of lymphoid follicles, interdigitating reticulum cells, and Langerhans cells. Expression is high on CD14⁺ and CD16⁺ monocytes and upregulated by IL-10, IL-6, and dexamethasone. LPS and PMA induce shedding of CD163 into plasma or supernatant. CD163 binds hemoglobin/haptoglobin complexes in a calcium- and pH-dependent manner, showing higher affinity for multimeric haptoglobin (HP1F) complexes. It also triggers intracellular signaling cascades involving tyrosine kinase-dependent calcium mobilization, inositol triphosphate production, and secretion of IL6 and CSF1.
Usage
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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