Thermo Fisher Scientific Rb Monoclonal Antibody (7E4B8)
Rb 단백질을 인식하는 Mouse monoclonal antibody(7E4B8)로, Human 시료에 반응합니다. IHC(P) 및 ELISA 실험에 적합하며, 액상 형태로 제공됩니다. 단기 4℃, 장기 -20℃ 보관 권장. 연구용 전용 제품입니다.
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Applications and Tested Dilution
Immunohistochemistry (Paraffin) [IHC (P)]
- Dilution: 1:200–1:1,000
ELISA
- Dilution: 1:10,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 7E4B8 |
| Immunogen | Purified recombinant fragment of human RB expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4 °C short term; for long-term, store at −20 °C (avoid freeze/thaw cycles) |
| Shipping Conditions | Wet ice |
| RRID | AB_10980913 |
Product Specific Information
MA5-15240 targets RB in indirect ELISA and IHC applications, showing reactivity with human samples. The immunogen is a purified recombinant fragment of human RB expressed in E. coli.
Target Information
Rb is a tumor suppressor nuclear phosphoprotein capable of binding to DNA. It is phosphorylated on serine and threonine residues but not on tyrosine. It forms complexes with SV40 large T antigen, adenovirus E1A, and human papillomavirus-16 E. Rb protein regulates transcription, and loss of its function leads to uncontrolled cell growth. Aberrations in the RB gene are implicated in cancers of the breast, colon, prostate, kidney, nasopharynx, and leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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