Thermo Fisher Scientific CD8 Monoclonal Antibody (2.43)
Thermo Fisher Scientific CD8 Monoclonal Antibody (Clone 2.43)은 마우스 CD8a+ 림프구를 검출하는 데 사용되는 Rat IgG2b 항체입니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합하며, 단백질 G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:20 | View 1 publication |
| Flow Cytometry (Flow) | 1:50 | View 2 publications |
| Functional Assay (Functional) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Fruit fly, Mouse |
| Host / Isotype | Rat / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2.43 |
| Immunogen | Mouse CTL clone L3 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1 mg/mL BSA, 30% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2536854 |
Product Specific Information
Flow cytometry analysis of MA1-145 shows positive staining of CD8a+ mouse TK-1 lymphocytes. This antibody is not recommended for Western blot.
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin family of receptors. It plays a critical role in signal transduction, T cell differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer of CD8α and CD8β, functioning as a co-receptor with the T cell receptor (TCR) for MHC class I molecules.
CD8α is essential for MHC-I binding and is also found as a homodimer on subsets of T cells, NK cells, monocytes, and dendritic cells.
Engagement of MHC-I/peptide complexes by antigen-presenting cells (APCs) recruits Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are vital for pathogen and tumor cell clearance. Differentiation of naive CD8+ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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