Thermo Fisher Scientific Phospho-IRE1 alpha (Ser724) Polyclonal Antibody
Phospho-IRE1 alpha (Ser724) 폴리클로날 항체로, 인간·마우스·랫트 시료에서 ER 스트레스 신호전달 연구에 적합. Western blot에 최적화(1:500–1:3,000 희석). 항원 친화 크로마토그래피 정제, 고농도 액상 형태로 제공. 장기 보관 시 -20°C 권장.
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Thermo Fisher Scientific Phospho-IRE1 alpha (Ser724) Polyclonal Antibody
Applications
- Western Blot (WB)
Tested Dilution: 1:500–1:3,000
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Carrier-protein conjugated synthetic peptide corresponding to residues around human IRE1 (phospho Ser724) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7, with 1% BSA, 20% glycerol |
| Contains | 0.025% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792877 |
Product Specific Information
- Keep as concentrated solution.
- Predicted reactivity: Mouse (100%), Rat (100%), Japanese Medaka (100%).
- Positive Control: Neuro2A, C8D30, NIH-3T3, C2C12, Rat2, HepG2, HepG2 (3 μM Thapsigargin treatment for 12 hr).
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
ERN1 serine/threonine kinase, also known as endoplasmic reticulum to nucleus signaling 1 (IRE1), is a human homologue of the yeast Ire1 gene product. It possesses intrinsic kinase and endoribonuclease activities essential for ER-based stress signaling.
IRE1 acts as a sensor for unfolded proteins in the ER, initiating the unfolded protein response by splicing XBP1 mRNA into an active transcriptional activator. It is critical for fetal viability and cell survival under stress conditions that cause protein misfolding in the ER.
Depletion of IRE1p has minimal effect under normal conditions but induces apoptosis under ER stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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