Thermo Fisher Scientific CD31 Monoclonal Antibody (CO.3E1D4), FITC

Applications

• Flow Cytometry (Flow)
  Tested Dilution: Neat
  View 1 publication

Product Specifications

Additional Formats

• Unconjugated
• Request custom conjugation

Product Specific Information

For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.
Mouse anti-Sheep CD31 antibody, clone CO.3E1D4 recognizes ovine CD31 (PECAM-1). Ovine CD31 is predominantly expressed by peripheral blood platelets and a small percentage of lymphocytes.

Target Information

CD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling via dual immunoreceptor tyrosine-based inhibitory motifs (ITIM). Upon phosphorylation, these motifs provide docking sites for protein-tyrosine phosphatases.
CD31 is expressed ubiquitously within the vascular compartment and located mainly at junctions between adjacent cells. Its N-terminal Ig-like domain mediates homophilic binding, essential for cell-cell interactions.
CD31 plays diverse roles in:

• Integrin-mediated cell adhesion
• Transendothelial migration
• Angiogenesis and apoptosis
• Negative regulation of immunoreceptor signaling
• Autoimmunity and macrophage phagocytosis
• IgE-mediated anaphylaxis and thrombosis

It is a key regulatory molecule in the vascular system.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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