Thermo Fisher Scientific v-Myb Polyclonal Antibody
Human, Mouse, Rat에서 반응하는 Rabbit Polyclonal v-Myb 항체. Western blot에 적합하며, 항원 친화 크로마토그래피로 정제됨. 액상 형태, 1 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications
- Western Blot (WB): 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 221–270 of Human v-Myb |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718950 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. Purity is greater than 95% as determined by SDS-PAGE.
Target Information
A-Myb is expressed at specific times in reproductive tissues, certain neural cells, and a subset of normal and neoplastic B lymphocytes. Both A-Myb and B-Myb are expressed in t(14:18) lymphoma cells, where they inhibit cell arrest and apoptotic signaling. Expression of B-Myb rescues cells from p53-induced G1 phase arrest mediated by p21, while A-Myb functions as an anti-apoptotic factor by activating the bcl-2 promoter, thereby up-regulating Bcl-2 expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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