Thermo Fisher Scientific PRKAR1A Polyclonal Antibody
PRKAR1A 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF에 사용 가능. 높은 순도의 항체로 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제되어 신뢰성 높은 연구용 시약.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 271–320 of Human PKA Iα regulatory subunit |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2718951 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
cAMP is a signaling molecule crucial for various cellular functions. It activates cAMP-dependent protein kinase, which phosphorylates target proteins. The inactive kinase holoenzyme consists of two regulatory and two catalytic subunits. Upon cAMP binding, the holoenzyme dissociates into regulatory dimers and free catalytic monomers.
This gene encodes one of the regulatory subunits involved in this process. It acts as a tissue-specific extinguisher down-regulating liver gene expression in hepatoma × fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). It can fuse with the RET protooncogene to form the thyroid tumor-specific chimeric oncogene PTC2.
A nonconventional nuclear localization sequence (NLS) suggests a role in DNA replication by serving as a nuclear transport protein for the second subunit of Replication Factor C (RFC40). Three alternatively spliced transcript variants encoding the same protein have been observed.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지: PA5-75223_PRKAR1A_P10644-1_Rabbit.svg)
(이미지: PA5-75223_PRKAR1A_P10644-1_Rabbit_PDP.jpeg)
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