Thermo Fisher Scientific c-Fos Monoclonal Antibody (5B10), PerCP
c-Fos 단백질을 검출하기 위한 PerCP 결합 단클론 항체. Western blot 및 IHC에 적합하며, 1:1,000(WB), 1:100(IHC) 희석 권장. 482/675 nm 파장에서 형광 검출 가능. 4°C 보관, 연구용 전용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000
- Reference: -
Immunohistochemistry (IHC)
- Tested Dilution: 1:100
- Reference: -
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 5B10 |
| Immunogen | Synthetic peptide from the N-terminal of Human c-Fos (aa. 280–380) |
| Conjugate | PerCP |
| Excitation / Emission Max | 482 / 675 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
A 1:1,000 dilution of MA5-45888 was sufficient for detection of c-Fos in 10 µg of serum-starved HeLa cells treated with PMA by ECL immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Detects a 62 kDa band. The observed molecular weight is higher than the predicted 41 kDa due to post-translational modifications.
Target Information
FBJ murine osteosarcoma viral oncogene homolog, commonly known as Cellular proto-oncogene Fos (c-Fos), belongs to the Fos transcription factor family and is encoded by the C-FOS gene on chromosome 14.
c-Fos heterodimerizes with c-Jun to form the Activator Protein-1 (AP-1) transcription factor, which regulates transcription of several genes involved in signal transduction, cell proliferation, and differentiation.
It is phosphorylated by multiple stimuli including growth factors and insulin at several sites. The best-known upstream kinase for phosphorylation at Threonine 232 is ERK MAPK, which regulates nuclear localization of c-Fos and its transcriptional activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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