Thermo Fisher Scientific CD137 (TNFRSF9) Monoclonal Antibody (OTI7C3)
CD137(TNFRSF9) 단일클론 항체로, 인간 시료에 반응하며 Flow Cytometry에 적합합니다. HEK293T 세포에서 발현된 재조합 단백질을 면역원으로 사용했습니다. 동결건조 형태로 제공되며, 재구성 후 1 mg/mL 농도로 사용 가능합니다. 연구용으로만 사용됩니다.
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Applications
- Flow Cytometry (Flow): 1:100
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7C3 |
| Immunogen | Full length human recombinant protein of human TNFRSF9 (NP_001552) produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform desalting again (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
CD137 (also known as TNFRSF9 or 4-1BB) is an inducible costimulatory molecule expressed mainly on activated T cells.
Its ligand, 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells.
CD137 signaling supports the survival and clonal expansion of activated and CD8+ memory T cells, while suppressing myelopoiesis and dendritic cell development.
Activation of CD137 induces cytokine release that regulates peripheral monocyte survival.
Soluble CD137 may act as a negative regulator in certain immune responses.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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