Thermo Fisher Scientific COL11A1 Polyclonal Antibody

Applications

Immunohistochemistry (IHC)

• Tested Dilution: Not specified
• View 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:50–1:200

Product Specifications

Product Specific Information

• Detects endogenous protein at a molecular weight of 181 kDa.
• Purity >95% by SDS-PAGE.

Target Information

Collagen Type XI is an 1806 amino acid protein belonging to the fibrillar collagen family. It plays an important role in fibrillogenesis by regulating the lateral growth of collagen II fibrils.
This protein forms trimers composed of three different chains: α1(XI), α2(XI), and α3(XI), with α3(XI) being a post-translational modification of α1(II).
α1(V) can also substitute for α3(XI). Collagen Type XI has three named isoforms (A, B, C) and additional isoforms arising from alternative exon usage (IIA or IIB).
Exon IIA and IIB transcripts are present in cartilage, with IIB preferentially used in tendon.
Collagen Type XI contains a single collagen-binding TSP N-terminal (TSPN) domain and is expressed in cartilage, placenta, and some tumor or virally transformed cell lines.
Isoform expression can be tissue-specific.
Defects in the COL11A gene cause Stickler syndrome type 2 (STL2), or beaded vitreous type, characterized by irregularly thickened fiber bundles in the vitreous cavity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.