Thermo Fisher Scientific GRID2 (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitution:
  Reconstitute with 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW), depending on sample size.
  The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
  The reconstituted solution can be stored at 4°C for up to 1 week. For long-term storage, aliquot and store at -20°C.
  Avoid multiple freeze/thaw cycles. Centrifuge antibody preparations before use (10,000 × g, 5 min).

Target Information

GRID2 is a member of the ionotropic glutamate receptor family, the predominant excitatory neurotransmitter receptors in the mammalian brain.
The encoded protein is a multi-pass membrane protein expressed selectively in cerebellar Purkinje cells.
A point mutation in the mouse ortholog, associated with the lurcher phenotype, leads to ataxia due to selective apoptosis of Purkinje cells during postnatal development.
Homozygous mutants die shortly after birth due to massive neuronal loss in the mid- and hindbrain.
GRID2 also plays a role in synapse organization between parallel fibers and Purkinje cells.
Alternate splicing results in multiple transcript variants encoding distinct isoforms.
Mutations in this gene cause cerebellar ataxia in humans.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.