Thermo Fisher Scientific Phospho-PDPK1 (Ser241) Recombinant Rabbit Monoclonal Antibody (PDK1S241-F7), PE
인산화 PDPK1(Ser241)을 검출하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체로, PE 형광 표지되어 유세포분석에 적합합니다. 높은 특이성과 재현성을 제공하며, 인간 시료에 반응하고 Protein A/G로 정제되었습니다.
- 카탈로그번호
- MA537089
- 판매단위
- pk
카탈로그
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Thermo Fisher Scientific Phospho-PDPK1 (Ser241) Recombinant Rabbit Monoclonal Antibody (PDK1S241-F7), PE
Applications
- Flow Cytometry (Flow): 5 µL / 1×10⁶ cells
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | PDK1S241-F7 |
| Immunogen | A synthetic phospho-peptide corresponding to residues surrounding Ser241 of human phospho PDPK1 |
| Conjugate | PE (R-Phycoerythrin) |
| Excitation / Emission Max | 565 / 576 nm |
| Form | Liquid |
| Purification | Protein A/G |
| Storage Buffer | PBS with 0.20% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897023 |
Additional Formats
Target Information
PDPK1 (3-Phosphoinositide Dependent Protein Kinase 1) phosphorylates AGC kinases and activates conventional PKC and PKC zeta through phosphorylation of threonine residues in the activation loop. It also phosphorylates Protein Kinase B (PKB/Akt) at threonine 308 in the presence of phosphatidylinositol-3,4,5-trisphosphate. Active Akt inactivates Glycogen Synthase Kinase 3 (GSK3), leading to activation of glycogen synthase and stimulation of glycogen synthesis. Due to its role in insulin-induced glycogen synthesis and PKC activation, PDPK1 is an important target in metabolic drug research.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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