Thermo Fisher Scientific C10orf54 Monoclonal Antibody (OTI7A6D5), TrueMAB
C10orf54(VISTA) 단백질을 인식하는 마우스 모노클로날 항체로, Western blot과 유세포분석에 사용 가능. 고순도 친화크로마토그래피 정제, 액상 형태로 제공. 인간 시료에 반응하며 암 면역치료 연구에 적합.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7A6D5 |
| Immunogen | Full length human recombinant protein of human C10ORF54 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
VISTA (V-domain Ig containing suppressor of T-cell activation), also known as B7-H5 or PD-1H, is a product of the VSIR gene. Although VISTA bears sequence homology to PD-L1, it has a distinct expression pattern. In both mouse and human, VISTA is predominantly expressed on hematopoietic cells, with the highest levels on myeloid cells and lower levels on T cells. It is typically absent on B cells.
VISTA expressed by antigen-presenting cells has been shown to suppress proliferation and cytokine production of CD4 and CD8 T cells, making it a potential target for cancer immunotherapy. Reported ligands include CD28H, VSIG-3, and VSIG-8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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