Thermo Fisher Scientific Phospho-GSK3B (Tyr216, Tyr279) Polyclonal Antibody
Western blot, IHC, ELISA 등 다양한 응용에 사용 가능한 다중 종 반응성 항체. Human, Mouse, Rat에 반응하며, Tyr216/Tyr279 인산화 부위에 특이적. 항원 친화 크로마토그래피로 정제된 Rabbit Polyclonal IgG. 연구용으로 적합.
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- 44604G
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 19 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry - Free Floating (IHC (Free)) | - | View 1 publication |
| ELISA | Assay-dependent | - |
| Immunoprecipitation (IP) | - | View 1 publication |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | The antiserum was produced against a chemically synthesized phosphopeptide derived from a region of human GSK-3α/β that contains tyrosine 279/216. The sequence is conserved in rat and zebrafish GSK-3α and mouse, rat, frog, and zebrafish GSK-3β. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Dulbecco’s PBS, pH 7.3, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533691 |
Target Information
GSK3B is a proline-directed serine/threonine protein kinase involved in energy metabolism, neuronal cell development, and body pattern formation. It negatively regulates glucose homeostasis and participates in energy metabolism, inflammation, ER-stress, mitochondrial dysfunction, and apoptotic pathways.
GSK3B is a key component of the Wnt/β-catenin signaling pathway, mediating β-catenin degradation and inhibiting Wnt signaling. It is also involved in Hedgehog, Notch, and insulin signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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