Thermo Fisher Scientific Phospho-PYK2 (Tyr402) Polyclonal Antibody, Alexa Fluor 488
Alexa Fluor 488로 표지된 Phospho-PYK2 (Tyr402) 항체로, Western blot 및 세포면역염색에 사용 가능. Rabbit polyclonal 형태로 고특이성 인산화 타이로신 인식. 액상 형태로 -20°C 보관, 연구용으로 적합.
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- 44618A1
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- pk
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Miscellaneous PubMed (Misc) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Published species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | This antibody was produced against a chemically synthesized phosphopeptide derived from the region of Pyk2 that contains tyrosine 402. The antibody was affinity purified by sequential epitope-specific chromatography, then conjugated to Alexa Fluor® 488 under optimal conditions. |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice (domestic); Wet or Dry ice (international) |
| RRID | AB_2533696 |
Target Information
PTK2B (FAK2) is a cytoplasmic tyrosine kinase involved in calcium-induced regulation of ion channels and activation of the MAP kinase signaling pathway. PTK2B regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading, and bone remodeling.
FAK2 plays a role in the regulation of the humoral immune response and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells.
It functions in signaling downstream of integrin and collagen receptors, immune receptors, G-protein coupled receptors, cytokine, chemokine, and growth factor receptors, and mediates responses to cellular stress.
Aberrant FAK2 expression may play a role in cancer cell proliferation, migration, and invasion in tumor formation and metastasis. Elevated expression has been seen in gliomas, hepatocellular carcinoma, lung cancer, and breast cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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