Thermo Fisher Scientific Lamin B2 Monoclonal Antibody (E-3)
Lamin B2 단백질을 검출하는 Thermo Fisher Scientific의 E-3 클론 단일클론 항체. Western blot, IHC, ICC/IF, IP 등 다양한 응용에 적합. Mouse IgG1, kappa 형식이며 Protein A로 정제된 액상 형태. -20°C 보관, 연구용 전용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5 - 3 µg/mL | View 12 publications |
| Immunohistochemistry (IHC) | - | View 8 publications |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 10 µg/mL | View 7 publications |
| Immunoprecipitation (IP) | 5 µg | View publications |
| Miscellaneous PubMed (Misc) | - | View 3 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Chicken, Human, Mouse, Rat |
| Published Species | Dog, Human, Mouse, Rat |
| Host/Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | E-3 |
| Immunogen | Extracts from chicken nuclei |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533107 |
Available Conjugated Formats
Target Information
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished: A-type and B-type lamins.
A-type lamins include lamin A, lamin C, and lamin Adel 10, derived from the same gene by alternative splicing.
B-type lamins include lamin B1 and lamin B2, arising from two distinct genes.
Mutations in A-type lamins are associated with rare dominant genetic disorders such as:
- Emery-Dreifuss muscular dystrophy
- Dilated cardiomyopathy with conduction-system disease
- Dunnigan-type familial partial lipodystrophy
A-type lamins are expressed during cell differentiation and interact with chromatin, suggesting a role in regulating differential gene expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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