Thermo Fisher Scientific STAT4 Monoclonal Antibody (ST4-5D6)
STAT4 단백질을 표적으로 하는 Mouse monoclonal 항체로 Western blot, ICC/IF, IP, Gel Shift에 사용 가능. Human, Mouse, Rat 반응성. Protein A로 정제된 액상 형태이며 PBS buffer에 0.1% sodium azide 포함. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–3 µg/mL | View 2 publications |
| Immunocytochemistry (ICC/IF) | 1:100 | – |
| Immunoprecipitation (IP) | 5 µg | – |
| Gel Shift (GS) | 1–5 µg/mL | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Mouse, Rat, Virus |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ST4-5D6 |
| Immunogen | A synthetic peptide derived from the C terminus of murine STAT4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2533108 |
Target Information
STAT4 was originally identified using degenerate primers complementary to sequences encoding conserved regions of other STAT proteins. The STAT4 protein shows similarity to STAT1 (52%) and STAT3 (47%). Functionally, STAT4 can be tyrosine phosphorylated by Jak1 or Jak2 and forms homo- or heterodimers with other STAT family members. Phosphorylated STAT4 binds the IFN-gamma activated site (GAS), and serine phosphorylation is required for maximal transcriptional activity.
STAT4 expression is restricted to thymus, spleen, and testis. It is activated by interleukin 12 (IL-12), which induces IFN-gamma production and promotes Th1 cell development for defense against intracellular pathogens. STAT4-deficient mice exhibit impaired Th1 development and enhanced Th2 differentiation. In viral infection, IFN-α/β activation of STAT4 is essential for IFN-γ production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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