Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), FITC, eBioscience

Thermo Fisher Scientific CD41a Monoclonal Antibody (eBioMWReg30 (MWReg30)), FITC, eBioscience™

Applications and Tested Dilution

Product Specifications

Additional Formats Available

• Unconjugated
• Alexa Fluor 700
• APC
• APC-eFluor 780
• Biotin
• eFluor 450
• Functional Grade
• NovaFluor Blue 510
• NovaFluor Blue 555
• NovaFluor Blue 660-120S
• NovaFluor Yellow 570
• NovaFluor Yellow 660
• PE
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Super Bright 645
• Request custom conjugation available

Product Specific Information

The eBioMWReg30 monoclonal antibody reacts with mouse CD41 (fibrinogen receptor, gpIIb, integrin alpha IIb). CD41 is expressed on platelets, megakaryocytes, and hematopoietic progenitors in embryo and adult stages. It forms a receptor complex with CD61 (gpIIIa, integrin beta III), playing a major role in platelet adhesion and aggregation by binding fibrinogen, fibronectin, and vitronectin.

Studies show that CD150⁺CD48⁻CD41⁻ expression identifies hematopoietic stem cells (HSC) with high efficiency for long-term multilineage reconstitution in irradiated mice.

Applications Reported: Flow cytometric analysis
Applications Tested: Flow cytometric analysis of mouse platelets, ≤0.125 µg per test (100 µL volume).
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered

Target Information

CD41 (platelet glycoprotein IIb, ITGA2B) comprises two subunits (120 kDa alpha and 23 kDa beta) that interact with CD61 in the presence of calcium to form an adhesive receptor. It mediates platelet aggregation and binds von Willebrand factor, fibrinogen, fibronectin, and vitronectin. Expressed mainly in megakaryocyte-platelet lineage and early hematopoietic differentiation stages.

Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet-type 16 bleeding disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without authorization.

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