Thermo Fisher Scientific CD41a Monoclonal Antibody (HIP8), FITC, eBioscience
인간 CD41a(Integrin αIIb)에 특이적인 마우스 단클론 항체로, FITC 형광 표지되어 있습니다. Flow Cytometry에 최적화된 사용 농도(5 µL/test)로 제공되며, 혈소판 및 거핵세포 표지에 적합합니다. 4°C 보관, 동결 금지.
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- 11-0419-4x (2개 옵션)
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Thermo Fisher Scientific CD41a Monoclonal Antibody (HIP8), FITC, eBioscience™
Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunocytochemistry (ICC/IF) | - | View 2 publications |
| Flow Cytometry (Flow) | 5 µL (0.25 µg)/test | View 15 publications |
| Immunomicroscopy (IM) | - | View 1 publication |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Bacteria, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HIP8 |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10717809 |
Available Formats
- Unconjugated
- APC
- APC-eFluor 780
- eFluor 450
- NovaFluor Blue 510
- NovaFluor Blue 585
- NovaFluor Blue 660-120S
- NovaFluor Yellow 590
- NovaFluor Yellow 660
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Custom conjugation available upon request
Product Specific Information
The HIP8 monoclonal antibody reacts with the human CD41 molecule (integrin alphaIIb, platelet GPIIb). CD41 forms a complex with integrin beta3 (GPIIIa, CD61) and is expressed in megakaryocytes and platelets. This complex serves as a receptor for fibronectin, fibrinogen, von Willebrand factor, vitronectin, and thrombospondin, mediating platelet aggregation. HIP8 antibody blocks platelet aggregation.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and validated for flow cytometry using human peripheral blood cells at 5 µL (0.25 µg)/test.
A test is defined as the amount of antibody that stains a cell sample in a final volume of 100 µL. Cell number may range from 10⁵ to 10⁸ cells/test.
Excitation: 488 nm
Emission: 520 nm
Laser: Blue Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
CD41 (platelet glycoprotein IIb, ITGA2B) consists of two subunits (120 kDa α and 23 kDa β) that interact with CD61 in the presence of calcium to form a functional adhesive receptor. CD41 mediates platelet aggregation and binds various proteins such as von Willebrand factor, fibrinogen, fibronectin, and vitronectin upon vascular injury. It is mainly expressed on the megakaryocyte-platelet lineage and appears during early hematopoietic differentiation.
Diseases associated with CD41 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 bleeding disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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